Sarah A. Stanley

Enhancement of a STING Agonist Vaccine for Tuberculosis Using Locally Supercharged MS2 Viral Capsids

This paper develops a vaccine platform using MS2 viral capsids to deliver an Mtb antigen and STING agonist, reducing the required dose and cost while maintaining efficacy.

Mycobacterium tuberculosis suppresses protective Th17 responses during infection

This study identifies factors by which Mycobacterium tuberculosis suppresses Th17 responses during infection, showing that ESX-1 and PDIM inhibit IL-23 production in dendritic cells.

An operon encoding two secreted nucleases mediates virulence in Methicillin-resistant Staphylococcus aureus

The paper identifies an operon in MRSA encoding two secreted nucleases that contribute to virulence, showing attenuation in a mouse model when mutated.

Host control of Mycobacterium tuberculosis infection is not influenced by the gut microbiome

This study uses a gnotobiotic mouse model to show that gut microbiome diversity does not affect Mtb lung burden, though it alters immune responses.

Reactive Oxygen Detoxification Contributes to Mycobacterium abscessus Antibiotic Survival

This study identifies ROS detoxification as critical for antibiotic survival in Mycobacterium abscessus, showing that antibiotics induce ROS which tolerant cells must neutralize.

Avoidance of MAIT cells is an essential determinant of Listeriamonocytogenes pathogenesis

This study shows that Listeria monocytogenes evades MAIT cells by lacking riboflavin biosynthesis, and engineered strains that produce riboflavin activate MAIT cells, offering therapeutic potential against infections and cancer.

A highly conserved two-gene operon is crucial for lipoarabinomannan localization, pathogenesis, and cell envelope function in Mycobacterium abscessus

This study identifies the lprg-mfs operon as essential for virulence, lipid distribution, and cell envelope integrity in Mycobacterium abscessus.

Random barcode transposon-site sequencing in Mycobacterium tuberculosis reveals the functions of uncharacterized genes

This study uses random barcode transposon-site sequencing in Mycobacterium tuberculosis to identify gene functions, revealing novel phenotypes and metabolic pathways.

Therapeutic Potential of Cyclodextrins Targeting Dengue Virus and SARS-CoV-2 Infection and Pathogenesis

This study evaluates cyclodextrins' ability to reduce endothelial dysfunction and antiviral activity against DENV and SARS-CoV-2 in vitro and in vivo.

Methylglyoxal is an antibacterial effector produced by macrophages during infection

This study shows that methylglyoxal, a byproduct of aerobic glycolysis in infected macrophages, acts as an antimicrobial effector that enhances host defense against bacterial pathogens.

Genome-wide, bidirectional CRISPR screens identify mucins as critical host factors modulating SARS-CoV-2 infection

The paper uses CRISPR screens to identify mucins as key host factors that restrict SARS-CoV-2 infection in human lung cells.