Author

Scott M. Brittain

Novartis (Switzerland)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1

Frequent Co-Authors

Dustin DovalaiD· 2 shared Markus SchirleiD· 2 shared Benika J. PinchiD· 1 shared Brynne Currier· 1 shared Christian E. StiegeriD· 1 shared Claudio R. ThomaiD· 1 shared Daniel K. NomuraiD· 1 shared Dennis L. BuckleyiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Dustin DovalaORCID

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Author profile →

2 papers

Recent·Most cited

Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC

Hannah T. Rosen, Kelvin Li, Christian E. Stieger, Erin L. Li, Brynne Currier, Scott M. Brittain, Francisco J. Garcia, Diana C. Beard, Michael D. Jones, Sandra Haenni‐Holzinger, Dustin Dovala, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, Daniel K. Nomura

This paper identifies a sulfinyl aziridine compound that selectively degrades MYC by targeting specific residues in its intrinsically disordered regions, demonstrating the potential of chiral small molecules for targeting undruggable proteins.

Angewandte Chemie International Edition · Sep 25, 2025Peer-reviewedCancer Biology

A Strategy to Assess the Cellular Activity of E3 Ligases against Neo-Substrates using Electrophilic Probes

Benika J. Pinch, Dennis L. Buckley, Scott Gleim, Scott M. Brittain, Laura Tandeske, Pier Luca D’Alessandro, Zachary J. Hauseman, Jennifer Lipps, Lei Xu, Edward P. Harvey, Markus Schirle, Elizabeth R. Sprague, William C. Forrester, Dustin Dovala, Lynn M. McGregor, Claudio R. Thoma

This paper introduces a method to assess E3 ligase activity against neo-substrates using electrophilic probes, demonstrating its effectiveness with VHL and SPSB2.

Cell chemical biology · Sep 8, 2021Peer-reviewedMolecular Biology