A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation
Aude Sylvain, Natacha Stoehr, Fupeng Ma, Artiom Cernijenko, Martin Schröder, Maryam Khoshouei, Melanie Vogelsanger, Michel Schoenboerner, Ashley A. Burke, Pasupuleti Rao, Jonathan M. Solomon, Joshiawa Paulk, Lei Xu, Janet Dawson, Damien Begue, , Zuni I. Bassi
This paper identifies NK7-902, a CRBN molecular glue degrader of NEK7, showing partial inhibition of NLRP3 inflammasome activation in humans and full activity in mice, but only transient effects in non-human primates.
Cell chemical biology · Jul 1, 2025Peer-reviewedImmunology