CD38 expression by neonatal human naïve CD4+ T cells shapes their distinct metabolic state and high tolerogenic potential
Laura R. Dwyer, Andrea M. DeRogatis, Sean Clancy, Victoire Gouirand, Charles Chien, Elizabeth E. Rogers, Scott P. Oltman, Laura L. Jelliffe‐Pawlowski, Theo van den Broek, Femke van Wijk, Susan V. Lynch, Rachel Lena Rutishauser, Allon Wagner, Alexis J. Combes, Tiffany C. Scharschmidt
This study shows neonatal human naive CD4+ T cells have higher CD38 expression, linking it to glycolytic metabolism and tolerogenic function compared to adult cells.
Journal of Clinical Investigation · Feb 26, 2026Peer-reviewedImmunology