Author

Charles Chien

University of California, Berkeley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

Allon WagneriD· 2 shared Abigail MendeiD· 1 shared Alexis J. CombesiD· 1 shared Alissa BockmaniD· 1 shared Andrea M. DeRogatisiD· 1 shared Chenyu ZhangiD· 1 shared David H. RauletiD· 1 shared Eglė Jurgaitytė· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Allon WagnerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Intra-Tumoral Treg Ablation Unleashes NK Cell-Mediated Control of CD8 T Cell-Resistant Tumors

Chenyu Zhang, Charles Chien, Eglė Jurgaitytė, Koharu Sakiyama, Alissa Bockman, Yeara Jo, Seungwon Lee, Stephanie L. Silveria, Elizabeth Andrews, Abigail Mende, Lily Zhang, K. Christopher García, Allon Wagner, Michel J.P. DuPage, David H. Raulet

Intra-tumoral Treg ablation enhances NK cell-mediated tumor control by restoring IL-2 production, effective against both MHC I+ and MHC I- cancers without systemic toxicity.

Science Immunology · Apr 10, 2026Peer-reviewedImmunology

CD38 expression by neonatal human naïve CD4+ T cells shapes their distinct metabolic state and high tolerogenic potential

Laura R. Dwyer, Andrea M. DeRogatis, Sean Clancy, Victoire Gouirand, Charles Chien, Elizabeth E. Rogers, Scott P. Oltman, Laura L. Jelliffe‐Pawlowski, Theo van den Broek, Femke van Wijk, Susan V. Lynch, Rachel Lena Rutishauser, Allon Wagner, Alexis J. Combes, Tiffany C. Scharschmidt

This study shows neonatal human naive CD4+ T cells have higher CD38 expression, linking it to glycolytic metabolism and tolerogenic function compared to adult cells.

Journal of Clinical Investigation · Feb 26, 2026Peer-reviewedImmunology