Author

Sean E. Guy

University of California San Diego

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Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:yeast· 1

Frequent Co-Authors

Alena MartsuliD· 1 shared Justin R. MeyeriD· 1 shared Krypton CarolinoiD· 1 shared Michael S. OvertoniD· 1 shared Omar S. AkbariiD· 1 shared Sergey KryazhimskiyiD· 1 shared Xingsen CheniD· 1 shared

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2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperEvolutionary Biology

Alena MartsulORCID

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1 paper

Recent·Most cited

Evolutionary BiologyG3 Genes Genomes GeneticsPeer-reviewedFeb 18, 2026

Experimental Test of Evolutionary Safety of a CRISPR-Cas9 Gene-Drive Element

Michael S. Overton, Sean E. Guy, Xingsen Chen…·Sergey Kryazhimskiy

The paper tests the evolutionary safety of CRISPR-Cas9 gene drives in yeast by measuring their impact on mutation rates and loss-of-heterozygosity, finding minimal effects.

5 citations

yeastexperimental assay

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