Krypton Carolino

The paper tests the evolutionary safety of CRISPR-Cas9 gene drives in yeast by measuring their impact on mutation rates and loss-of-heterozygosity, finding minimal effects.

This paper develops a chemogenomic platform using Plasmodium berghei artificial chromosomes to identify antimalarial drug targets through barcode sequencing and validation in Plasmodium falciparum.

The paper uses in vitro evolution in haploid human cells to identify drug resistance mechanisms and validates them through gene expression experiments.

The paper identifies genetic determinants of chemical resistance in yeast using in vitro evolution and whole genome sequencing, revealing key transcription factors involved in drug resistance.