Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells
Gökçe G. Agsu, Yuze Cao, Diyan Jain, Stanley E. Strawbridge, Sam Daly, Ziwei Zhang, Annabelle Wurmser, Kathryn Bowers, Igor Orsine de Almeida, Gergő Nikolényi, Sebastian Berger, Mantas Jonaitis, K.A. Gumaa, Tekle Pauzaite, Smitha Maretvadakethope, , Srinjan Basu
The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.
bioRxiv · Dec 3, 2025 · PreprintCell Biology