Author

Tekle Pauzaite

University of CambridgeORCID 0000-0002-0668-3661Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

James A. NathaniD· 3 shared Anneliese O. SpeakiD· 2 shared Brian M. OrtmanniD· 2 shared James A.C. BertliniD· 2 shared Adrian Llewellyn HarrisiD· 1 shared Ahmed M. SalmaniD· 1 shared Alexander HandysideiD· 1 shared Anastasia C. HepburniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

James A. NathanORCID

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3 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedApr 6, 2026

SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinoma.

Brian M. Ortmann, Tekle Pauzaite, James A.C. Bertlin…·James A. Nathan

This study shows SET1B maintains HIF activity in ccRCC, correlates with disease progression, and is a target for HIF-2 inhibitors.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyNature CommunicationsPeer-reviewedMar 12, 2026

VHL synthetic lethality screens uncover CBF-beta as a negative regulator of STING

James A.C. Bertlin, Tekle Pauzaite, Qian Liang…·James A. Nathan

The paper identifies CBF-beta as a negative regulator of STING through synthetic lethality screens in VHL-null ccRCC cells, showing its role in type I interferon signaling and tumor growth.

4 citationstop 3%

humanCRISPR screen

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Cell BiologybioRxivPreprintDec 3, 2025

Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells

Gökçe G. Agsu, Yuze Cao, Diyan Jain…·Srinjan Basu

The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.

DOI 10.64898/2025.12.03.691924

humanfluorescence / live-cell microscopy

𝕏 PostBluesky