Author

Smitha Maretvadakethope

Imperial College LondonORCID 0000-0002-7269-0659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Rubén Perez‐CarrascoiD· 3 shared Àlex HaroiD· 1 shared Àngela Pantebre Pedrosa· 1 shared Annabelle WurmseriD· 1 shared Brian HendrichiD· 1 shared David HolcmaniD· 1 shared David KlenermaniD· 1 shared Diyan JainiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersSystems Biology

Rubén Perez‐CarrascoORCID

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3 papers

Recent·Most cited

Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells

Gökçe G. Agsu, Yuze Cao, Diyan Jain, Stanley E. Strawbridge, Sam Daly, Ziwei Zhang, Annabelle Wurmser, Kathryn Bowers, Igor Orsine de Almeida, Gergő Nikolényi, Sebastian Berger, Mantas Jonaitis, K.A. Gumaa, Tekle Pauzaite, Smitha Maretvadakethope, , Srinjan Basu

The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.

bioRxiv · Dec 3, 2025 · PreprintCell Biology

Let there be multifunctionality: Uncovering the criticality zoo of the AC-DCgenetic circuit

Smitha Maretvadakethope, Içvara Aor, Matthias M. Fischer, Àngela Pantebre Pedrosa, Yolanda Schaerli, Rubén Perez‐Carrasco

The paper analyzes the AC-DC genetic circuit to show it can exhibit diverse multifunctional dynamics, including coexisting oscillations and multistability, challenging traditional views of network constraints.

bioRxiv · Aug 22, 2025 · PreprintSystems Biology

Local Nearby Bifurcations Lead to Synergies in Critical Slowing Down: the Case of Mushroom Bifurcations

Mariona Fucho-Rius, Smitha Maretvadakethope, Rubén Perez‐Carrasco, Àlex Haro, Tomás Alarcón, Josep Sardanyés A

The paper studies transient dynamics near multiple bifurcations in gene regulatory networks, showing synergistic effects and noise-driven control of transition timing.

Physical review. E · Feb 28, 2025Peer-reviewedSystems Biology