Pablo Antonio Kuri-Morales

Genetic analyses of blood pressure traits in 140,000 admixed adults from Mexico City

This study conducts GWAS on blood pressure traits in 140,559 admixed Mexican adults, identifying novel genetic signals and highlighting ancestry-specific heterogeneity.

Enhanced power and transferability for genetics-driven metabolomic biomarker discovery in admixed American cohorts

The paper improves metabolomic biomarker discovery in admixed American cohorts by training models on diverse data, achieving better predictive performance and more significant associations with cardiometabolic diseases.

PKHD1L1 affects fertility in women

The paper investigates the effect of the PKHD1L1 splice donor variant rs17368310 on female fertility, showing reduced child count in homozygous carriers across Finnish and Mexican populations.

Extending Genome-Wide Association Studies to admixed cohorts with high degrees of relatedness

The paper introduces Tractor-Mix, a mixed model method for GWAS in admixed cohorts with high relatedness, improving ancestry-specific association detection and controlling false positives.

Type 2 diabetes genetics in 125,000 admixed adults from Mexico City

This study identifies 86 T2D GWAS associations in 125,000 admixed Mexican adults, including 21 novel signals, and highlights the role of common regulatory variation in the endocrine pancreas.

Direct effect of genetic ancestry on complex traits in a Mexican population

The paper estimates direct effects of genetic ancestry on complex traits in a Mexican population using family-based analyses and finds significant associations for height and type 2 diabetes but not for educational attainment.

Comparative analysis of 136,401 Admixed Americans and 419,228 Europeans reveals ancestry-specific genetic determinants of clonal haematopoiesis

This study compares clonal haematopoiesis (CH) between admixed Americans and Europeans, finding ancestry-specific genetic factors and lower CH prevalence in admixed populations.

Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease

The paper identifies protein-truncating variants in BSN associated with severe adult-onset obesity, type 2 diabetes, and fatty liver disease, with no effect on childhood adiposity.

A deep catalog of protein-coding variation in 985,830 individuals

This paper presents the largest catalog of human protein-coding variation from 985,830 individuals, identifying rare variants and their functional implications for precision medicine.

Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations

This paper improves genetic scores for adiposity traits in East Asian populations by using trans-ancestry meta-analysis, increasing variance explained compared to European-derived scores.

Genotyping, sequencing and analysis of 140,000 adults from the Mexico City Prospective Study

The paper genotypes and sequences 140,000 adults from the Mexico City Prospective Study, revealing ancestry diversity and developing imputation resources for genetic studies.