Author

AstraZeneca Genomics Initiative

AstraZeneca (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:GWAS / association mapping· 2 Assay:proteomics· 2 Research Focus:gene regulatory network inference· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Slavé PetrovskiiD· 4 shared Adam PlattiD· 3 shared Dimitrios VitsiosiD· 3 shared Katherine R. SmithiD· 3 shared Keren CarssiD· 3 shared Oliver S. BurreniD· 3 shared Quanli WangiD· 3 shared Ryan S. DhindsaiD· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenomics

Slavé PetrovskiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants

Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner, Yi‐Hsiang Hsu, Tom G. Richardson, Praveen Surendran, Anubha Mahajan, Chloe Robins, Steven G. Grinnell, Liping Hou, Erika M. Kvikstad, Oliver S. Burren, Jonathan Davitte, Kyle L. Ferber, , Christopher D. Whelan

The paper maps genetic associations with plasma proteins in 54,306 UK Biobank participants, identifying 10,248 new protein quantitative trait loci (pQTLs) and expanding the genetic architecture of the plasma proteome.

Nature · Oct 4, 2023Peer-reviewedGenetics

Genetic architecture of telomere length in 462,675 UK Biobank whole-genome sequences

Oliver S. Burren, Ryan S. Dhindsa, Sri V. V. Deevi, Sean Wen, Abhishek Nag, Jonathan Mitchell, Fengyuan Hu, Katherine R. Smith, Neetu Razdan, Henric Olsson, Adam Platt, Dimitrios Vitsios, Qiang Wu, AstraZeneca Genomics Initiative, Veryan Codd, , Slavé Petrovski

The paper identifies 53 rare variants and 22 genes associated with telomere length using UK Biobank whole-genome sequences, highlighting their role in clonal haematopoiesis and disease.

medRxiv · Sep 18, 2023 · PreprintGenetic & Genomic Medicine

Influences of rare protein-coding genetic variants on the human plasma proteome in 50,829 UK Biobank participants

Ryan S. Dhindsa, Oliver S. Burren, Benjamin B. Sun, Bram Peter Prins, Dorota Matelska, Eleanor Wheeler, Jonathan Mitchell, Erin Oerton, Ventzislava A. Hristova, Katherine R. Smith, Keren Carss, Sebastian Wasilewski, Andrew Robert Harper, Dirk S. Paul, Margarete A. Fabre, , Slavé Petrovski

The paper identifies rare protein-coding variants influencing plasma protein levels in 50,829 UK Biobank participants using exome-wide association studies.

bioRxiv · Oct 9, 2022 · PreprintGenomics

Surveying the contribution of rare variants to the genetic architecture of human disease through exome sequencing of 177,882 UK Biobank participants

Quanli Wang, Ryan S. Dhindsa, Keren Carss, Andrew Robert Harper, Abhishek Nag, Ioanna Tachmazidou, Dimitrios Vitsios, Sri V. V. Deevi, Alex Mackay, Daniel Muthas, Michael H. Hühn, Susan J. Monkley, Henric Olsson, Sebastian Wasilewski, Katherine R. Smith, , AstraZeneca Genomics Initiative

This study uses exome sequencing of 177,882 UK Biobank participants to assess the role of rare variants in 10,533 phenotypes, identifying 911 significant gene-phenotype relationships.

bioRxiv · Dec 13, 2020 · PreprintGenomics