Author

Sebastien Bonnet

Medical University of South Carolina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam J. BrownsteiniD· 1 shared Candance Guerrero· 1 shared Christopher J. RhodesiD· 1 shared Emilia M. Swietlik· 1 shared Jason S. HongiD· 1 shared Jeffrey C. BlakeiD· 1 shared Jenna B. MendelsoniD· 1 shared Joanna Pepke‐ŻabaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Adam J. BrownsteinORCID

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1 paper

Recent·Most cited

Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy

Madelyn J. Blake, Jason S. Hong, Adam J. Brownstein, Christopher J. Rhodes, Emilia M. Swietlik, Jeffrey C. Blake, Ryan A. Moon, Lynn M. Hartweck, Jenna B. Mendelson, Sasha Z. Prisco, Todd W. Markowski, LeeAnn Higgins, Kevin J. Murray, Candance Guerrero, Sandra Breuils‐Bonnet, , Kurt W. Prins

This study shows that impaired BCAA metabolism promotes ferroptosis, leading to pulmonary arterial hypertension and associated liver disease, and that targeting BCAA metabolism can alleviate these effects.

JACC Basic to Translational Science · May 30, 2026Peer-reviewedMolecular Biology