The PTPN1 and PTPN2 phosphatases are Cooperative Regulators of Cancer Cell Immune Evasion
Alexandre Poirier, Erika Walback, Rui Jun Su, Isabelle Aubry, Chenyue Wu, Elisabeth St-Laurent, Sonali Uttam, Ana Maria Hincapie, Bianca Colalillo, Serge Hardy, Samuel Doré, Michel L. Tremblay
This study identifies PTPN1 and PTPN2 as cooperative regulators of cancer immune evasion, showing their inhibition enhances immune response and synergizes with anti-PD1 therapy.
bioRxiv · Jul 2, 2025 · PreprintCancer Biology