Author

Sonali Uttam

McGill University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Arkady KhoutorskyiD· 2 shared Jeffrey S. MogiliD· 2 shared Luda B. DiatchenkoiD· 2 shared Marc ParisieniD· 2 shared Alain PacisiD· 1 shared Alba Ureña GuzmániD· 1 shared Aleksandra OgurtsovaiD· 1 shared Alexa Fiorante· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Arkady KhoutorskyORCID

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Author profile →

4 papers

Recent·Most cited

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

Kevin C. Lister, Calvin Wong, Sonali Uttam, Marc Parisien, Patricia Stecum, Nicole Brown, Weihua Cai, David Ho-Tieng, Mehdi Hooshmandi, Ning Gu, Mehdi Amiri, Francis Beaudry, Seyed Mehdi Jafarnejad, Diana Tavares‐Ferreira, Nikhil Nageshwar Inturi, , Arkady Khoutorsky

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

eLife · Mar 31, 2026Peer-reviewedNeuroscience

Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Tricia R. Cottrell, Jeffrey S. Roskes, Michael Fotheringham, Emily Cohen, Boyang Zhang, Logan L Engle, Daphne Wang, Elizabeth Will, Joel Chaim Sunshine, Daniel Jiménez‐Sánchez, Zhen Zeng, Justina X. Caushi, Jiajia Zhang, Nina M. D’Amiano, Julie Stein Deutsch, , Janis Marie Taube

The paper develops a spatial biomarker, DONUTS, to predict treatment response in lung cancer by analyzing the niche surrounding CD8+FoxP3+ T-cells.

bioRxiv · Aug 13, 2025 · PreprintPathology

The PTPN1 and PTPN2 phosphatases are Cooperative Regulators of Cancer Cell Immune Evasion

Alexandre Poirier, Erika Walback, Rui Jun Su, Isabelle Aubry, Chenyue Wu, Elisabeth St-Laurent, Sonali Uttam, Ana Maria Hincapie, Bianca Colalillo, Serge Hardy, Samuel Doré, Michel L. Tremblay

This study identifies PTPN1 and PTPN2 as cooperative regulators of cancer immune evasion, showing their inhibition enhances immune response and synergizes with anti-PD1 therapy.

bioRxiv · Jul 2, 2025 · PreprintCancer Biology

Single-cell RNA sequencing reveals time- and sex-specific responses of spinal cord microglia to peripheral nerve injury and links ApoE to neuropathic pain

Shannon N. Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain Pacis, Marc Parisien, Oded Rabau, Lisbet Haglund, Jean Albert Ouellet, Carlo Santaguida, Jiannis Ragoussis, Ji Zhang, Michael W. Salter, Luda B. Diatchenko, Luke M. Healy, , Arkady Khoutorsky

This study uses single-cell RNA sequencing to analyze spinal cord microglia responses to nerve injury, identifying sex- and time-specific changes and a role for ApoE in neuropathic pain.

bioRxiv · Dec 9, 2020 · PreprintNeuroscience