SMYD3 protein degraders in HPV-negative head and neck squamous cell carcinoma.
Jawad Akhtar, Sai Reddy Doda, William Moore, Mohd Saleem Dar, Shafagh Valipour, Sohyoung Kim, Jianghong Wu, Yong Wan, Meiye Jiang, Arfa Moshiri, John Schneekloth, Sudipto Das, Þorkell Andrésson, Rolf E. Swenson, Vassiliki Saloura
This study develops SMYD3 proteolysis targeting chimeras (PROTACs) for HPV-negative head and neck squamous cell carcinoma, showing effective SMYD3 degradation and reduced oncogenic activity.
bioRxiv · Sep 29, 2026 · PreprintCancer Biology