Sohyoung Kim

This study develops SMYD3 proteolysis targeting chimeras (PROTACs) for HPV-negative head and neck squamous cell carcinoma, showing effective SMYD3 degradation and reduced oncogenic activity.

This study identifies SUV420H1 as a driver in HPV-negative HNSCC, showing its role in proliferation, invasion, and immune evasion, and suggests targeting it to improve immunotherapy response.

The paper defines a temporally resolved framework for GR-mediated gene regulation, identifying three binding classes and their functional links to transcriptional output.

This study identifies primary target pathways of progerin in HGPS patients through transcriptomic analysis, revealing mTORC1, UPR, UV response, apoptosis, and TNF signaling as key affected pathways.

The paper identifies a novel GR mutation causing partial glucocorticoid resistance and shows its impact on development and endocrine regulation through patient-derived cells and a knock-in mouse model.

The paper presents a new crystal structure of agonist-bound GR-LBD and proposes a model for GR multimerization, reconciling structural and functional data on glucocorticoid resistance.

The paper identifies LxxLL motifs in NIPBL that regulate its interaction with MAU2 and steroid receptors, forming a ternary complex with GR to facilitate enhancer localization of cohesin.