Author

Jianghong Wu

Reaction Biology Corporation (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Cancer Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ajit Jadhav· 1 shared Anton SimeonoviD· 1 shared Arfa MoshiriiD· 1 shared biao Wang· 1 shared ding Yang· 1 shared Dorian M. Cheff· 1 shared Ekaterina Kuznetsova· 1 shared Haiching Ma· 1 shared

Activity by Year

2016-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

Ajit Jadhav

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Author profile →

3 papers

Recent·Most cited

SMYD3 protein degraders in HPV-negative head and neck squamous cell carcinoma.

Jawad Akhtar, Sai Reddy Doda, William Moore, Mohd Saleem Dar, Shafagh Valipour, Sohyoung Kim, Jianghong Wu, Yong Wan, Meiye Jiang, Arfa Moshiri, John Schneekloth, Sudipto Das, Þorkell Andrésson, Rolf E. Swenson, Vassiliki Saloura

This study develops SMYD3 proteolysis targeting chimeras (PROTACs) for HPV-negative head and neck squamous cell carcinoma, showing effective SMYD3 degradation and reduced oncogenic activity.

bioRxiv · Sep 29, 2026 · PreprintCancer Biology

Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome Substrate

Nathan P. Coussens, Stephen C. Kales, Mark J. Henderson, Olivia W. Lee, Kurumi Y. Horiuchi, Yuren Wang, Qing Chen, Ekaterina Kuznetsova, Jianghong Wu, Dorian M. Cheff, Ken Chih-Chien Cheng, Paul Shinn, Kyle R. Brimacombe, Min Shen, Anton Simeonov, , Matthew D. Hall

This study identifies five small molecule inhibitors of NSD2 through high-throughput screening and validates their activity in cell-based assays.

bioRxiv · Oct 24, 2017 · PreprintCancer Biology

Transcriptome Analysis Reveals Skin Lipid Metabolism Related to Wool Diameter in Sheep

Shaoyin Fu, YunXia Qi, Xiaolong He, Lai Da, biao Wang, rigele Te, jianghong Wu, ding Yang, yongbin Liu, wengguang Zhang

This study uses RNA-Seq to analyze skin transcriptomes of sheep with different wool diameters, identifying differentially expressed genes related to lipid metabolism that may influence wool diameter.

bioRxiv · May 2, 2016 · PreprintGenetics