Tau-mediated synaptic dysfunction is coupled with HCN channelopathy
Despoina Goniotaki, Francesco Tamagnini, Luca Biasetti, Svenja-Lotta Rumpf, Claire Troakes, Saskia J. Pollack, Shalom Ukwesa, Haoyue Sun, Igor Kraev, Louise C. Serpell, Wendy J. Noble, Kevin Staras, Diane P. Hanger
The paper shows that HCN channel dysfunction is linked to tauopathies, with altered synaptic structure and function in Alzheimer's and Tau35 mouse models.
Alzheimer s & Dementia · Jul 12, 2024Peer-reviewedNeuroscience