Francesco Tamagnini

A Practical Refinement of Golgi Staining for Cortical Neuronal Morphology

This paper introduces a modified Golgi staining protocol for mouse cortical tissue that improves workflow efficiency and consistency for neuronal morphology visualization.

Psilocybin ameliorates neuropathic pain-like behaviour in mice and facilitates gabapentin-mediated analgesia

This study shows psilocybin reduces neuropathic pain in mice and enhances gabapentin's effectiveness through 5-HT2A receptor mechanisms.

Longitudinal assessment of the conversion of mild cognitive impairment into Alzheimer's dementia: Observations and mechanisms from neuropsychological testing and electrophysiology

This study identifies biomarkers for predicting mild cognitive impairment conversion to Alzheimer's dementia using EEG, neuropsychological tests, and mathematical models.

Tau-mediated synaptic dysfunction is coupled with HCN channelopathy

The paper shows that HCN channel dysfunction is linked to tauopathies, with altered synaptic structure and function in Alzheimer's and Tau35 mouse models.

Inferring parameters of pyramidal neuronexcitability in mouse models of Alzheimer'sdisease using biophysical modeling and deeplearning

This paper introduces DeepHM, a method combining deep learning and biophysical modeling to infer ion channel conductance changes in Alzheimer's mouse models.

Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal - medial prefrontal cortex circuit during natural sleep in APPNL-G-F mice

This study examines network impairments in APPNL-G-F mice during sleep, finding NREM-specific changes in mPFC spindles and hippocampal SWRs linked to PV interneuron dysfunction.

EEG microstate complexity for aiding early diagnosis of Alzheimer's disease

This study uses EEG microstate complexity and spectral measures to improve early diagnosis of Alzheimer's disease with high sensitivity and specificity.

Imbalance in the response of pre- and post-synaptic components to amyloidopathy

The paper examines how Aβ plaques develop and affect synaptic density and turnover in a mouse model of Alzheimer's disease, finding an imbalance in pre- and post-synaptic responses.