Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs
Priyanka Patel, Courtney N. Buchanan, Matthew D. Zdradzinski, Pabitra Kumar Sahoo, Amar N. Kar, Seung Joon Lee, Lauren S. Vaughn, Anatoly Urisman, Juan A. Osés-Prieto, Michela Dell’Orco, Devon E. Cassidy, Irene Dalla Costa, Sharmina Miller, Elizabeth L. Thames, Terika P. Smith, , Jeffery L. Twiss
This study identifies KHSRP as an axonal RNA-binding protein whose mRNA is locally translated after nerve injury, leading to mRNA destabilization and slowed axon regeneration.
Nucleic Acids Research · May 9, 2022Peer-reviewedNeuroscience