Schizophrenia risk conferred by protein-coding de novo mutations
Daniel P. Howrigan, Samuel A. Rose, Kaitlin E. Samocha, Menachem Fromer, Felecia E. Cerrato, Wei J. Chen, Claire L. Churchhouse, Kimberly Chambert, Sharon D. Chandler, Mark J. Daly, Ashley Dumont, Giulio Genovese, Hai‐Gwo Hwu, Nan M. Laird, Jack A. Kosmicki, , Benjamin M. Neale
This study examines the contribution of protein-coding de novo mutations to schizophrenia risk using whole-exome sequencing data from parent-offspring trios, finding a modest but polygenic effect.
bioRxiv · Dec 13, 2018 · PreprintGenetics