Ming T. Tsuang

Genetic and environmental contributions to eigengene expression

The paper estimates genetic and environmental contributions to module eigengenes (MEs) derived from blood lymphocytes in older male twins, finding significant heritability in 56% of detected MEs.

Linking Choroid Plexus Enlargement with Plasma Analyte and Structural Phenotypes in Clinical High Risk for Psychosis: A Multisite Neuroimaging Study

This study finds that individuals at clinical high risk for psychosis have larger choroid plexus volumes, associated with neuroanatomical changes and plasma analyte markers.

Polygenic resilience scores capture protective genetic effects for Alzheimers disease

This study identifies genetic resilience factors for Alzheimer's disease by constructing polygenic resilience scores that reduce genetic risk penetrance and correlate with polygenic risk scores in unaffected individuals.

Improving Polygenic Prediction in Ancestrally Diverse Populations

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

The paper identifies shared disruptive coding mutations between schizophrenia, autism spectrum disorders, and other developmental disorders, suggesting overlapping molecular aetiology.

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

Genetic and clinical analyses of psychosis spectrum symptoms in a large multi-ethnic youth cohort reveal significant link with ADHD.

The paper investigates genetic risk for psychosis spectrum symptoms in youth, finding a significant link with ADHD polygenic scores and age-specific effects.

BrainGENIE: The Brain Gene Expression and Network Imputation Engine

BrainGENIE predicts brain-tissue gene expression from peripheral blood transcriptomes, outperforming existing methods in accuracy and biological relevance.

Reliability of Mismatch Negativity Event-Related Potentials in a Multisite, Traveling Subjects Study

The paper evaluates MMN reliability across multiple EEG sites using different preprocessing methods, finding that mastoid referencing improves reliability.

Comparative genetic architectures of schizophrenia in East Asian and European populations

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.

Progressive reconfiguration of resting-state brain networks as psychosis develops: Preliminary results from the North American Prodrome Longitudinal Study (NAPLS) consortium

The paper examines longitudinal changes in resting-state brain networks in individuals at clinical high risk for psychosis and finds reduced network efficiency and increased diversity in those who later develop psychosis.

Schizophrenia risk conferred by protein-coding de novo mutations

This study examines the contribution of protein-coding de novo mutations to schizophrenia risk using whole-exome sequencing data from parent-offspring trios, finding a modest but polygenic effect.

PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways Across Biological Sex And Modes Of Trauma

This study identifies shared and sex-specific inflammatory pathways in PTSD through a meta-analysis of blood transcriptomes across different trauma types and biological sexes.

Toward leveraging big data in human functional connectomics: Generalization of brain graphs across scanners, sessions, and paradigms

The paper assesses the reliability of functional connectomic measures across different scanners, sessions, and paradigms, finding fair to excellent reliability and demonstrating achievable statistical power in multisite studies.