Wei J. Chen

This study evaluates the immunogenicity of an LP.8.1-adapted BNT162b2 vaccine against JN.1 sublineages, showing higher neutralizing antibody responses compared to other adapted vaccines.

Omicron JN.1- and KP.2-adapted BNT162b2 mRNA vaccines elicit stronger neutralizing antibody responses against circulating sublineages than previous vaccines, supporting annual strain updates.

The paper identifies 979 novel genetic loci for 36 quantitative traits by analyzing data from the Taiwan Biobank, Biobank Japan, and UK Biobank, highlighting the value of diverse populations in GWAS.

The paper introduces the Taiwan Biobank, a large-scale biobank with genetic and phenotypic data from 150,000 individuals, highlighting its population structure and potential for genetic research.

This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

Exomes of 24,248 schizophrenia cases and 97,322 controls implicate ultra-rare damaging variants in 10 genes, including GRIN2A and GRIA3, with odds ratios of 3 to 50.

The paper identifies shared disruptive coding mutations between schizophrenia, autism spectrum disorders, and other developmental disorders, suggesting overlapping molecular aetiology.

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.

This study examines the contribution of protein-coding de novo mutations to schizophrenia risk using whole-exome sequencing data from parent-offspring trios, finding a modest but polygenic effect.