Daniel S. Tylee

Gene Discovery and Biological Insights into Anxiety Disorders from a Multi-Ancestry Genome-wide Association Study of >1.2 Million Participants

This study identifies 51 anxiety-associated genetic loci from a multi-ancestry GWAS of 1.2 million participants and highlights genetic correlations with other mental and physical health conditions.

Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records

This study investigates the genetic and longitudinal relationship between posttraumatic stress disorder and coronary artery disease using genome-wide data and electronic health records.

Sex differences, cross-ancestry generalizability, and noise-smoking interactions in the polygenic architecture of hearing loss in adults

This study identifies 54 risk loci for hearing loss in adults across multiple cohorts, revealing sex differences, ancestry-specific polygenic risks, and interactions with environmental factors like noise and smoking.

Drinking and smoking polygenic risk is associated with neurodevelopmental outcomes of children and young adults independently of psychopathology and substance use.

The paper investigates the association between polygenic risk scores for drinking and smoking behaviors and neurodevelopmental outcomes in children and young adults, finding independent effects from psychopathology and substance use.

Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.

The paper investigates genetic correlations between psychiatric and immune-related phenotypes using GWAS summary data, finding significant shared genetic variants.

PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways Across Biological Sex And Modes Of Trauma

This study identifies shared and sex-specific inflammatory pathways in PTSD through a meta-analysis of blood transcriptomes across different trauma types and biological sexes.