Predictable Engineering of Signal-DependentCis-Regulatory Elements
Jake Cornwall-Scoones, Dirk Benzinger, Tianji Yu, Alberto Pezzotta, Andreas Sagner, Lina Gerontogianni, Shaun Bernadet, Elizabeth Finnie, Giulia L. M. Boezio, Hannah T. Stuart, Manuela Melchionda, Oliver C K Inge, Bianca Dumitrascu, James Briscoe, M. Joaquina Delàs
The paper develops a method to engineer synthetic cis-regulatory elements that control gene expression in response to signals, showing they can be designed using quantitative rules.
bioRxiv · Mar 7, 2025 · PreprintDevelopmental Biology