Andreas Sagner

microRNAs control temporal patterning of the vertebrate nervous system

This study shows that microRNAs, specifically let-7 and miR-9 families, regulate the timing of neuronal identity transitions in the developing vertebrate nervous system by controlling temporal transcription factors.

The neuronal fate determinants SOX4/11 control mitotic fidelity of adult hippocampal precursor cells

This study shows that SOX4/11 transcription factors are critical for mitotic fidelity in adult hippocampal precursor cells, with loss leading to mitotic defects and cell death.

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors

The paper shows that a sequence of transcription factors drives the chronological diversification of spinal neuron subtypes in motor and sensory circuits.

Predictable Engineering of Signal-DependentCis-Regulatory Elements

The paper develops a method to engineer synthetic cis-regulatory elements that control gene expression in response to signals, showing they can be designed using quantitative rules.

Astrocyte-derived PEA116 increases adult hippocampal neurogenesis and confers stress resilience

This study identifies PEA116, an astrocyte-derived peptide that enhances adult hippocampal neurogenesis and stress resilience by promoting aNSC proliferation through ERK2 phosphorylation.

Temporal patterning of the central nervous system by a shared transcription factor code

The paper identifies a temporal patterning program in vertebrate neurons controlled by transcription factors and the TGFβ pathway, showing its role in generating neuronal diversity.

Precision of Tissue Patterning is Controlled by Dynamical Properties of Gene Regulatory Networks

The paper shows that gene regulatory network structure influences boundary precision in tissue patterning by modulating stochastic fluctuations, not reducing noise.

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord

scRNA-seq of 21465 mouse neural tube cells (e9.5-e13.5) maps spinal progenitor and neuron types, validates new subtype markers, and reveals temporally staged transcription-factor modules.

Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics

The paper uses single cell transcriptomics to study Olig2 and Hes regulatory dynamics during motor neuron differentiation, revealing Olig2's role in repressing Hes5 and coordinating differentiation timing.