Jake Cornwall-Scoones

Solid-like PAR protein assemblies encode long-term spatial memory of cell polarity during suspended animation

The paper shows that PAR-3 proteins form stable clusters during anoxia in C. elegens embryos, preserving polarity information for rapid reactivation after metabolic arrest.

Minimal essential requirements for neural tube self-organisation

The paper shows that RA induces a transient co-expression state of PAX6 and FOXA2 in neural tube organoids, leading to two opposing cell fates that determine cell-type proportions through feedback signaling.

Multiscale mechanics drive functional maturation of the vertebrate heart

This study investigates how multiscale mechanical and chemical interactions drive the functional maturation of the zebrafish heart during development.

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

Predictable Engineering of Signal-DependentCis-Regulatory Elements

The paper develops a method to engineer synthetic cis-regulatory elements that control gene expression in response to signals, showing they can be designed using quantitative rules.

Notochord and axial progenitor generation by timely BMP and NODAL inhibition during vertebrate trunk formation

The paper uses single-cell transcriptomics to study vertebrate trunk formation, identifying signaling pathways that regulate notochord and tissue development in human pluripotent stem cells.

Patterning and folding of intestinal villi by active mesenchymal dewetting

This study identifies an active mechanical mechanism involving PDGFRA+ mesenchymal cells that pattern and fold intestinal villi through myosin II-dependent forces and matrix metalloproteinase-mediated tissue fluidization.

Transcriptional control of apical protein clustering drives de novo cell polarity establishment in the early mouse embryo

This study identifies transcriptional control and protein clustering as mechanisms driving cell polarity establishment in early mouse embryos.