Giulia L. M. Boezio

Entropy Sorting Feature Selection: information-theoretic gene set identification improves single-cell RNA sequencing data interpretability

ESFS improves scRNA-seq data interpretability by identifying gene sets with complex expression dynamics, outperforming traditional methods in diverse biological contexts.

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding

The paper uses genomic barcoding and single-cell RNA sequencing to reveal hierarchical lineage architecture in human and avian spinal cord development, showing conserved lineage restriction and developmental routes.

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

VISIBLE: An imaging-driven system for sampling, biofabrication, and manipulation of complex biological models

VISIBLE is a system for real-time manipulation and bioprinting of complex in vitro models, enabling precise interventions and improving reproducibility in biomedical research.

Multimodal profiling unveils a reversible breast basal-like cell state in AKT-inhibitor resistant tumours

This study identifies a reversible basal-like cell state in AKT-inhibitor resistant triple negative breast cancer using multimodal profiling and lineage tracing.

Predictable Engineering of Signal-DependentCis-Regulatory Elements

The paper develops a method to engineer synthetic cis-regulatory elements that control gene expression in response to signals, showing they can be designed using quantitative rules.

Protein degradation shapes developmental tempo in mouse and human neural progenitors

The paper compares protein dynamics in mouse and human neural progenitors, finding that human NPs have longer protein half-lives and lower proteasomal activity, which influences developmental tempo.

PUFFFIN: A novel, ultra-bright, customisable, single plasmid system for labelling cell neighbourhoods

PUFFFIN labels cell neighbourhoods using a fluorescent protein fusion, enabling tracking of cell interactions and profiling non-cell-autonomous responses in mammalian cells.

The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth

This study shows that epicardial impairment in zebrafish leads to smaller ventricles due to defective cardiomyocyte growth, highlighting the role of FGF and VEGF signaling in cardiac morphogenesis.

Endothelial TGF-β signaling instructs smooth muscle development in the cardiac outflow tract

This study shows that endothelial TGF-β signaling is crucial for cardiac outflow tract development, as its disruption leads to OFT dilation and SMC disorganization, which can be partially rescued by fibulin-5 modulation.

Integration of multiple imaging platforms to uncover cardiac defects in adult zebrafish

The paper combines multiple imaging techniques to detect cardiac defects in adult zebrafish that were previously undetectable.

Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract

The paper shows that cardiac function affects endocardial cell dynamics, which in turn shape the cardiac outflow tract in zebrafish.

Cardiac valve regeneration in adult zebrafish: importance of TGF-β signaling in new tissue formation

This study shows adult zebrafish can regenerate cardiac valves after decellularization, with TGF-β signaling promoting this process by enhancing progenitor cell proliferation and differentiation.

Genetic compensation is triggered by mutant mRNA degradation

The paper shows that mutant mRNA degradation triggers transcriptional adaptation in zebrafish and mouse, leading to upregulation of related genes.

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists

The paper identifies insulin-independent modulators of glucose metabolism using a zebrafish model and finds androgen receptor antagonists reduce fasting glucose levels in insulin mutants.