Weiping Han

UP-REGULATION OF SYNAPTOBREVIN-2 TO DELAY AGE-RELATED COGNITIVE IMPAIRMENT

This study shows that overexpressing synaptobrevin-2 in mice delays age-related cognitive decline by improving synaptic function and memory.

AAV-mediated delivery of leptin but not adiponectin improves metabolic health in a mouse model of congenital generalised lipodystrophy

This study evaluates AAV-mediated delivery of leptin and adiponectin in a mouse model of congenital generalized lipodystrophy, finding that leptin improves metabolic health while adiponectin does not.

A hybrid machine learning framework leveraging biophysicochemical insights for scalable discovery of protein-ligand interactions

The paper introduces a hybrid machine learning framework that improves protein-ligand interaction prediction by combining biophysicochemical insights with large-scale representations, achieving faster and more accurate virtual screening.

Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution

This paper develops an optogenetic tool to control PKC epsilon activity with spatiotemporal precision and validates its function in phosphorylation events.

Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT

This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.

Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy

This paper evaluates tissue-selective AAV gene therapy for lipodystrophy in mice, finding that adipose-targeted vectors improve metabolic health without liver expression.

Maternal microbes and early brain development in mouse

This study shows that the maternal gut microbiome affects brain development in mice, with persistent structural changes observed even after microbial reintroduction.

Irradiation of UVC LED at 277 nm inactivates coronaviruses by photodegradation of spike protein.

This study compares the effectiveness of different UVC wavelengths in inactivating coronaviruses, finding that 277-nm UVC LED is most effective due to spike protein degradation.