Author

Sheue-Houy Tyan

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1

Frequent Co-Authors

Edward H. KooiD· 2 shared Brea Midthune· 1 shared Elena Vicario Orri· 1 shared Eric A. BushongiD· 1 shared Goonho ParkiD· 1 shared I‐Fang Ling· 1 shared Karen ChiangiD· 1 shared Katherine E. DeLoach· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Edward H. KooORCID

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2 papers

Recent·Most cited

Caspase cleavage of APP contributes to amyloid beta-protein induced synaptic injury

Brea Midthune, Goonho Park, Sheue-Houy Tyan, Edward H. Koo

The paper investigates how caspase cleavage of APP contributes to Aβ-induced synaptic dysfunction and spine loss in neurons.

bioRxiv · Apr 30, 2025 · PreprintNeuroscience

Aβ-induced synaptic injury is mediated by presynaptic expression of amyloid precursor protein (APP) in hippocampal neurons

Elena Vicario Orri, Kensaku Kasuga, Sheue-Houy Tyan, Karen Chiang, Silvia Viana da Silva, Eric A. Bushong, Katherine E. DeLoach, I‐Fang Ling, Liqun Luo, Mark H. Ellisman, Stefan Leutgeb, Edward H. Koo

This study shows that Aβ-induced synaptic injury in hippocampal neurons is mediated by presynaptic APP expression, as demonstrated by orientation-specific LTP reduction and synaptic loss.

bioRxiv · Jul 18, 2020 · PreprintNeuroscience