Kensaku Kasuga

Association of rare APOE missense variants with Alzheimer's disease in the Japanese population

The paper identifies APOE rare missense variants in the Japanese population and finds two variants associated with protective effects against Alzheimer's disease.

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

Aβ-induced synaptic injury is mediated by presynaptic expression of amyloid precursor protein (APP) in hippocampal neurons

This study shows that Aβ-induced synaptic injury in hippocampal neurons is mediated by presynaptic APP expression, as demonstrated by orientation-specific LTP reduction and synaptic loss.