Aβ-induced synaptic injury is mediated by presynaptic expression of amyloid precursor protein (APP) in hippocampal neurons
Elena Vicario Orri, Kensaku Kasuga, Sheue-Houy Tyan, Karen Chiang, Silvia Viana da Silva, Eric A. Bushong, Katherine E. DeLoach, I‐Fang Ling, Liqun Luo, Mark H. Ellisman, Stefan Leutgeb, Edward H. Koo
This study shows that Aβ-induced synaptic injury in hippocampal neurons is mediated by presynaptic APP expression, as demonstrated by orientation-specific LTP reduction and synaptic loss.
bioRxiv · Jul 18, 2020 · PreprintNeuroscience