Integrated in vivo and transcriptomic analyses of lethal Oropouche virus infection reveal suppression of pathogenic host responses by antiviral therapy
Cassia Sousa Moraes, Gabriel González, Akihiko Sato, Shigeru Miki, Atsuko Inoue, Koshiro Tabata, Joshua W. Kranrod, Chilekwa Frances Kabamba, Aiko Ohnuma, Keita Matsuno, Rio Harada, Shinji Saito, Naoki Akimoto, Michihito Sasaki, Yasuko Orba, , Yukari Itakura
This study shows favipiravir suppresses OROV replication and disease in hamsters, preventing neuroinvasion and pathogenic host responses through transcriptomic analysis.
PLoS Pathogens · Oct 7, 2026Peer-reviewedMicrobiology