Michihito Sasaki

Integrated in vivo and transcriptomic analyses of lethal Oropouche virus infection reveal suppression of pathogenic host responses by antiviral therapy

This study shows favipiravir suppresses OROV replication and disease in hamsters, preventing neuroinvasion and pathogenic host responses through transcriptomic analysis.

Interleukin-34 Promotes Activation of Disease-associated Microglia-like Cells and Attenuates Disease Progression in West Nile Virus Infection

This study shows IL-34 promotes DAM-like microglial activation and protects against WNV infection in cell culture and mice.

A surrogate marker of protection confirms the efficacy of an AddaS03-adjuvanted West Nile virus subunit vaccine

This study evaluates AddaS03 as an adjuvant for a WNV subunit vaccine, showing it elicits higher neutralizing antibody titers and provides full protection in mice compared to Alhydrogel.

Application of the CPER reverse genetics system for genetic engineering of rabies virus

This paper develops a CPER-based reverse genetics system for rabies virus, enabling the generation of recombinant viruses with various genetic modifications.

Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma

This study shows lysine lactylation at stress-response gene TSSs is enriched under glucose starvation in canine hemangiosarcoma and correlates with transcriptional activation.

Universal and quantitative detection of double-stranded RNAs as a signature of pan-virus infections using a luciferase-based biosensor

This study develops a luciferase-based biosensor to detect and quantify dsRNA from various viral infections, showing broad-spectrum reactivity and utility in assessing antiviral compounds.

Combinatorial approach with mass spectrometry and lectin microarray dissected glycoproteomic features of virion-derived spike protein of SARS-CoV-2

The paper identifies site-specific glycan compositions of SARS-CoV-2 spike protein using mass spectrometry and lectin microarray, revealing key glycan structures relevant to vaccine design.

LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19

LIGHTHOUSE identifies novel therapeutics for diseases including cancer, bacterial infections, and COVID-19 using a graph-based deep learning approach without requiring 3D structural data.