2-arm-PEG-oligocations transiently shield the liver sinusoids to mitigate off-target hepatic expression of mRNA lipid nanoparticles
Anjaneyulu Dirisala, Bhaskar Chatterjee, Le Bui Thao Nguyen, Kazuko Toh, Miki Matsui-Masai, Saed Abbasi, Xueying Liu, Theofilus A. Tockary, Nan Qiao, Junichi Ishikawa, Jumpei Norimatsu, Yuki Mochida, Shigeto Fukushima, Makoto Oba, Kazunori Kataoka, Satoshi Uchida
This paper demonstrates that 2-arm-PEG-oligocations transiently shield liver sinusoids to reduce off-target hepatic mRNA expression and improve iLNP delivery to spleen and tumors.
ACS Nano · Aug 18, 2026Peer-reviewedBioengineering