Expanded huntingtin CAG repeats disrupt the balance between neural progenitor expansion and differentiation in human cerebral organoids
Jinqiu Zhang, Jolene Ooi, Kagistia Hana Utami, Sarah R. Langley, Obed Akwasi Aning, Dong Shin Park, Magdalena Renner, Shiming Ma, Chit Fang Cheok, Juergen A. Knoblich, Florent Ginhoux, Enrico G. Petretto, Mahmoud A. Pouladi
This study shows that expanded CAG repeats in HTT disrupt neural progenitor expansion and differentiation in human cerebral organoids, suggesting abnormal neurodevelopment in Huntington disease.
bioRxiv · Nov 26, 2019 · PreprintDevelopmental Biology