Quantitative dialing of gene expression via precision targeting of KRAB repressor
Matthew S. Wilken, Christie Ciarlo, Jocelynn R. Pearl, Elaine V. Schanzer, Hanna Liao, Benjamin P. Van Biber, Konstantin Queitsch, Jordan E. Bloom, Alexander Joel Federation, Reyes Acosta, Shinny Vong, Ericka Otterman, Douglas Dunn, Hao Wang, Pavel Zrazhevskiy, , John A. Stamatoyannopoulos
This study demonstrates precise control of gene expression levels by targeting the KRAB repressor domain in human cells.
bioRxiv · Feb 19, 2020 · PreprintSynthetic Biology