Astrocyte-neuron mitochondrial transfer via mitoEVs supports neuronal energy metabolism and is impaired in early Alzheimer's disease
Liesbeth Voorbraeck, Jesús Alarcón-Gil, Romain Giraud, Francesca Pozzobon, Maria João Pereira, Shubin Guo, Zhibai Cao, Krizia Distefano, Mohammad Hossein Forouzanfar, Oscar P. B. Wiklander, Mite Mijalkov, Joana B. Pereira, Doste Rashid Mamand, Maria Ankarcrona, Luana Naia
This study identifies mitoEV-mediated mitochondrial transfer from astrocytes to neurons as a compromised pathway in early Alzheimer's disease, revealing its role in supporting neuronal energy metabolism.
bioRxiv · Mar 9, 2026 · PreprintNeuroscience