Romain Giraud

This study identifies mitoEV-mediated mitochondrial transfer from astrocytes to neurons as a compromised pathway in early Alzheimer's disease, revealing its role in supporting neuronal energy metabolism.

The paper investigates early synaptic dysfunction and emotional behavior in AppNL-F mice, finding reactive astrocytes contribute to synaptic mistuning before Aβ plaques and are linked to depressive-like behavior.