Doste Rashid Mamand

Customizable bead-based platform for EV surface protein immunocapture and detection in plasma

This paper introduces a customizable bead-based platform for isolating and detecting specific EV populations in plasma, demonstrating sensitivity and the ability to distinguish clinically relevant biomarker expressions.

Bioengineered extracellular vesicles mitigate neuroinflammation by neutralizing pneumolysin and delaying disease onset in experimental pneumococcal meningitis

This study develops bioengineered extracellular vesicles that neutralize pneumolysin and reduce inflammation in pneumococcal meningitis, improving survival in a mouse model.

Human growth plates house resting zone sub-populations with features of quiescent stem cells

This study characterizes gene expression in human growth plates, identifying novel markers and sub-populations of resting zone chondrocytes with features of quiescent stem cells.

Quantitative Assessment of shRNA Loading and Delivery Efficiency of Engineered Extracellular Vesicles

This study develops an engineered extracellular vesicle platform that improves shRNA loading and delivery efficiency, achieving robust gene silencing in multiple cell types and the mouse brain.

Cell Type Dependent Uptake of Extracellular Vesicles Independent of Cellular Origin

This study shows that extracellular vesicle uptake by recipient cells depends on cell type characteristics rather than the origin of the vesicles.

Systemic Inflammation Modulates Clearance and drives Extra-Hepatic Distribution of Extracellular Vesicles

This study shows that systemic inflammation significantly prolongs EV plasma half-life and enhances their accumulation in inflamed organs like the liver and spleen.

Astrocyte-neuron mitochondrial transfer via mitoEVs supports neuronal energy metabolism and is impaired in early Alzheimer's disease

This study identifies mitoEV-mediated mitochondrial transfer from astrocytes to neurons as a compromised pathway in early Alzheimer's disease, revealing its role in supporting neuronal energy metabolism.

Evaluation of Tetraspanins in Extracellular Vesicle Bioengineering

This study investigates the role of tetraspanins in EV bioengineering by knocking out CD9, CD63, and CD81 in HEK293T cells and shows increased engineered EV production upon reintroduction of tetraspanin-fusion constructs.

Efficient delivery of gene editors using intein-engineered virus-like particles

This paper develops intein-engineered virus-like particles for efficient gene editing delivery, achieving robust gene editing in multiple cell types and organs.

Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles

The paper identifies 24 novel scaffold proteins with conserved EV-sorting abilities, outperforming CD63 in cargo loading and demonstrating improved EV engineering potential.