Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics
Lu Zhao, Kevin Xu, Irina A. Talyzina, Jingyi Shi, Shisheng Li, Yaoheng Yang, Shuming Zhang, Jie Zheng, Alexander I. Sobolevsky, Hong Chen, Jianmin Cui
The paper engineers hTRPV4 to create an ultrasound-sensitive actuator for sonogenetics, showing improved mechano-sensitivity and reduced sensitivity to other stimuli.
bioRxiv · Oct 16, 2024 · PreprintBiophysics