Time-resolved cryo-EM reveals conformational trajectory of allosteric activation in isocitrate lyase
Jamie R. H. Taka, James Jung, Shuning Guo, Wanting Jiao, Brooke X. C. Kwai, Luiz Pedro S. de Carvalho, Matthew B. McNeil, Evelyn Yu‐Wen Huang, Zhiheng Yu, Ivanhoe K. H. Leung, Ghader Bashiri
The paper uses time-resolved cryo-EM to show how acetyl-CoA binding induces conformational changes in ICL2, leading to asymmetric catalytic activity.
bioRxiv · Apr 9, 2026 · PreprintBiochemistry