Shuo Han

Activation pathway of the human voltage-gated proton channel

This study determines the activation pathway of the human voltage-gated proton channel hHV1 using computational methods, revealing voltage-driven structural changes and lipid effects validated by experiments.

The structural dynamics and molecular coupling in the slow inactivation of a prokaryotic voltage-gated sodium channel

This study uses smFRET to reveal conformational changes in the prokaryotic NavAb channel during slow inactivation, identifying key residues that coordinate structural transitions.

Regulation of the human voltage-gated proton channel by membrane sterols

This study investigates how cholesterol and its analogs regulate the hHv1 proton channel by altering S4 segment conformation, identifying key residues and mechanisms involved.

Benchmarking Cell Type and Gene Set Annotation by Large Language Models with AnnDictionary

The paper benchmarks large language models for cell-type and gene set annotation using AnnDictionary, finding high accuracy in cell-type annotation and strong functional gene set recovery.

Nanosecond pulsed electric field precisely manipulates cytoplasmic Ca2+ oscillations during oocyte activation

This study uses nanosecond pulsed electric fields to manipulate Ca2+ signaling in oocytes, improving activation efficiency and developmental potential compared to traditional methods.