Somatic copy number mutations contribute to fitness in transplantation models of spontaneous human breast cancer metastasis
Hoa Tran, Gurdeep Singh, Hakwoo Lee, Damian Yap, Eric Lee, William Daniels, Farhia Kabeer, Ciara H. O’Flanagan, Vinci Au, Michael Van Vliet, Daniel Lai, Elena Zaikova, Sean Beatty, Esther Kong, Shuyu Fan, , Samuel A. J. R. Aparicio
This study shows that somatic copy number mutations (CNA) influence metastatic fitness in breast cancer by mediating transcriptional changes and affecting clone survival in different sites.
bioRxiv · Oct 27, 2025 · PreprintCancer Biology