Author
Eric Lee
BC Cancer AgencyORCID 0000-0003-2114-3118Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 44 mutual co-author links7 papers
Recent·Most cited
- BioinformaticsbioRxivPreprint
Single-cell spatial multi-omic characterization of the tumour microenvironment in transformed follicular lymphoma
Shaocheng Wu, Eric Lee, Anne-Sophie Fratzscher…·Andrew J. L. Roth
The paper uses multi-omic single-cell spatial techniques to study FL transformation, finding spatial shifts in B-cell neighborhoods and immunomodulatory interactions linked to disease progression.
DOI 10.64898/2026.08.11.743383 - Cancer BiologybioRxivPreprint
Somatic copy number mutations contribute to fitness in transplantation models of spontaneous human breast cancer metastasis
Hoa Tran, Gurdeep Singh, Hakwoo Lee…·Samuel A. J. R. Aparicio
This study shows that somatic copy number mutations (CNA) influence metastatic fitness in breast cancer by mediating transcriptional changes and affecting clone survival in different sites.
DOI 10.1101/2025.10.27.684911 - Cancer BiologybioRxivPreprint
Multidimensional characterization of cellular ecosystems in Hodgkin lymphoma
Tomohiro Aoki, Gerben Duns, Shinya Rai…·Christian Steidl
This study identifies four molecular subtypes of Hodgkin lymphoma using multimodal data, revealing distinct clinical features and immune ecosystem dynamics.
- GenomicsGenome biologyPeer-reviewed
Single cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers
Farhia Kabeer, Hoa Tran, Mirela Andronescu…·Samuel A. J. R. Aparicio
The paper identifies genomic and non-genomic contributions to drug resistance in triple negative breast cancer using single cell transcriptomics and copy number data.
- BioinformaticsBioinformaticsPeer-reviewed
ESQmodel: biologically informed evaluation of 2-D cell segmentation quality in multiplexed tissue images
Eric Lee, Dong‐Kyu Lee, Wayne Fan…·Andrew J. L. Roth
ESQmodel evaluates single-cell segmentation quality using expression data and a prior belief of cellular composition to compute per-cell entropy.
- BioinformaticsBioinformaticsPeer-reviewed
SpatialSort: A Bayesian Model for Clustering and CellPopulation Annotation of Spatial Proteomics Data
Eric Lee, Kevin T. Chern, Michael D. Nissen…·Andrew J. L. Roth
SpatialSort is a Bayesian clustering method for spatial proteomics data that integrates spatial information and prior knowledge to improve cell population annotation.
6 citations