Alexander A. Green

This paper introduces TONE, a rapid, isothermal biosensing platform for heavy metal detection using transcription-factor-gated DNA strand-displacement amplification, achieving low detection limits for copper and lead.

This paper introduces BINOCULAR, a system for rapid, multiplexed detection of Mycoplasma using toehold switch sensors, achieving sub-5-minute readout times and 1-copy/µL sensitivity.

The paper demonstrates that community-designed riboregulators outperform canonical designs and identifies structural features that influence translational activation.

The paper presents an automated plasmid assembly pipeline using liquid handling robotics to construct and test RNA sensors efficiently.

Toehold-VISTA designs RNA sensors using machine learning, improving function against SARS-CoV-2 RNA by integrating biophysical modeling and PLS-DA.

The paper introduces a nucleic acid device called CDA for point-of-care diagnosis using endogenous biomarkers, demonstrating high classification accuracy and efficient diagnostic strategies.

This paper develops synthetic cells that respond to pH changes by synthesizing and releasing proteins on demand.

The paper introduces RAMONA, a rapid, modular nanobody assay for antigen detection that combines portability with high sensitivity and adaptability for diverse targets.

This paper introduces a framework for model-informed mRNA design using integrated gradients and an agentic hypothesis engine, achieving improved in vivo expression.

The paper introduces SANDSTORM and GARDN, neural networks for predicting RNA function and designing functional RNA molecules, achieving improved performance over traditional methods.

This paper designs de-novo RNA-based translational repressors with multi-input logic capabilities for synthetic biology applications.