Deep learning-enabled scaffolding of spatial arrays of PfCSP epitopes
Nelson R. Wu, Karla M. Castro, Nathan Beutler, Wen-Hsin Lee, Sai Sundar Rajan Raghavan, Gregory M. Martin, Monika Jain, Sashank Agrawal, Alessia Liguori, Oleksandr Kalyuzhniy, Patrick D. Skog, Sierra Terada, Yen‐Chung Lai, Justin Ndihokubwayo, Danny Lu, , William R. Schief
This study uses deep learning to design multi-epitope scaffolds mimicking CSP's spatial structure, showing accurate positioning of two epitopes and partial success with the third.
Proceedings of the National Academy of Sciences · Apr 7, 2026Peer-reviewedImmunology