Simultaneous inhibition of DNA-PK and Pol{Theta} improves integration efficiency and precision of genome editing
Sandra Wimberger, Nina Akrap, Mike A. Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, , Marcello Maresca
This study identifies AZD7648 and Pol{Theta} inhibitors as a combination (2iHDR) that enhances CRISPR-Cas9 integration efficiency and precision by targeting DNA-PK and MMEJ repair pathways.
Nature Communications · Aug 14, 2023Peer-reviewedMolecular Biology