Author

Michael R. Slater

Promega (United States)ORCID 0000-0002-2803-0338Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Alison Donnelly AxtmaniD· 1 shared Amir Taheri‐GhahfarokhiiD· 1 shared Anders LundiniD· 1 shared Bastian SchiffthaleriD· 1 shared Björn Magnusson· 1 shared Burcu BestasiD· 1 shared Cameron Damgaard· 1 shared David Harold DrewryiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Alison Donnelly AxtmanORCID

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2 papers

Recent·Most cited

Cellular Context Influences Kinase Inhibitor Selectivity

M. Binder, Frances M. Bashore, Kaitlin K. Dunn Hoffman, Cameron Damgaard, Michael R. Slater, David Harold Drewry, Matthew B. Robers, Alison Donnelly Axtman

The paper compares cell-free and cellular assays for kinase inhibitor selectivity, finding divergent results and identifying new kinase interactions in cells.

Journal of Medicinal Chemistry · Feb 6, 2026Peer-reviewedCell Biology

Simultaneous inhibition of DNA-PK and Pol{Theta} improves integration efficiency and precision of genome editing

Sandra Wimberger, Nina Akrap, Mike A. Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, , Marcello Maresca

This study identifies AZD7648 and Pol{Theta} inhibitors as a combination (2iHDR) that enhances CRISPR-Cas9 integration efficiency and precision by targeting DNA-PK and MMEJ repair pathways.

Nature Communications · Aug 14, 2023Peer-reviewedMolecular Biology